G2 cyclins are required for the degradation of G1 cyclins in yeast
Article Abstract:
The G2 cyclins Clb1, Clb2, Clb3 and Clb4 bring about the proteolysis of the G1 cyclins Cln1 and Cln2 in yeast. The mechanism involves the coupling of G2 cyclins synthesis with the G1 cyclins degradation in the presence of the ubiquitin-conjugating enzyme, Ubc9. The Cdc34 ubiquitin-conjugating activity is similar to that of Ubc9 for the degradation of Cln1,2. It also promotes the degradation of Sic1, which is a specific inhibitor of Cdc28-Clb complexes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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p70s6k function is essential for G1 progression
Article Abstract:
Microinjection of p70s6k antibodies into the cytoplasm of REF-52 cells results in the failure of cells to enter the S phase of the cell cycle. Protein synthesis, DNA synthesis and c-fos expression were also suppressed after injection. Resumption of DNA synthesis after the reduction of antibodies indicate that the effects of p70s6k are reversible and non-toxic. These results indicate the role of p70s6k activity in the G1 phase of mitogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast
Article Abstract:
Research is presented concerning the monitoring of the spindle orientation of the actin cytoskeleton in Schizosaccharomyces pombe. The influence of a mitogen-activated protein kinase pathway on mitotic delay is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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