Gating pore current in an inherited ion channelopathy
Article Abstract:
Three mutations in gating-charge-carrying arginine residues in an S4 segment causing hypokalaemic periodic paralysis has induced a hyperpolarization-activated cationic leak through the voltage sensor of the skeletal muscle [Na.sub.v]1.4 channel. The results have shown gating pore current in naturally occurring disease mutations of an ion channel and a clear correlation between mutations that cause gating pore current and hypokalaemic periodic paralysis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A TRPV family ion channel required for hearing in Drosophila
Article Abstract:
Research demonstrates that Nanchung protein is an integral component of the chordotonal mechanotransducer in Drosophila as shown by the absence of antennal sound-evoked potentials in mice lacking this protein. The Nanchung protein is an ion channel subunit similar to vanilloid-receptor -related channels and is involved in calcium influx and cation currents. Furthermore, it is expressed in chordotonal neurons and localized to sensory cilia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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A welcome shortage of breath
Article Abstract:
The respiratory systems of animals should guarantee an efficient oxygen supply. However it seems that certain insects have evolved to restrict the flow of oxygen too.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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