Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
Article Abstract:
Multiple endocrine neoplasia type 2A (MEN 2A) is a prevalent cancer syndrome affecting the neural ectodermal derived tissues. Medullary Thyroid Carcinoma (MTC) and phaeochromocytoma are characteristic of the MEN 2A. At lower levels of the human thyroid and in MTC and phaeochromocytoma, a receptor tyrosine kinase gene, the RET photo-oncogene, is invested in the DNA segment. A recent study identified 20 RET proto-oncogene missense mutations from 23 apparently distinct MEN 2A families, but not in 23 normal controls. Of the 20 mutations, 19 affect similar conserved cysteine residue of the RET extracellular and transmembrane domains at the boundary.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Article Abstract:
The jumonji protein gene amplified in squamous cell carcinoma 1(GASC1 ), also known as jumonji domain containing 2 (JMJD2C), and its analogues JMJD2A and JMJD2B are shown to demethylate tri- and dimethylated lysine 9 on histone H3 (H3K9me3/me2). The ectopic expression of GASC1 or other JMJD2 members markedly decreases H3K9me3/me2 levels, increases H3K9me1 levels, delocalizes the repressive protein HP1and reduces heterochromatin in vivo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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In utero rearrangements in the trithorax-related oncogene in infant leukaemias
Article Abstract:
The leukaemogenic event originates in vitro, as is evidenced by three pairs of infant twins with concordant leukaemic who each share unique (clonal) but non-constitutive HRX rearragements in their leukaemic cells. They also support the intra-placental 'metastasis' hypothesis for leukaemic concordance in twins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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