Glial growth are alternatively spliced erbB2 ligands expressed in the nervous system
Article Abstract:
A Schwann cell mitogen, termed glial growth factor (GGF), was purified from bovine pituitary and the GGF gene was cloned. The gene codes for multiple GGF factors differing in molecular mass. Further investigation showed that in addition to GGF, the gene also codes for specific activators of p185(super erb) receptor tyrosine kinase and the neu differentiation factor. These different factors are the product of differential splicing of the GGF transcript. In situ hybridization analysis showed that the different trophic factors are expressed in the nervous system during embryonic development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression
Article Abstract:
The aggregation of neuregulins at synaptic sites and the remnants of neuregulins at the synaptic sites when nerve and muscle cells are absent is demonstrated using antibodies. The erbB3 mRNA and the erbB2 mRNA with less erbB4 mRNA are found in the C2 muscle cells. Tyrosine phosphorylation in erbB2 and erbB3 is stimulated by neuregulins, revealing that erbB2 and erbB3 mediate neuregulin signalling in skeletal muscles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
Article Abstract:
A new study of the vanilloid receptor-1 reveals that its presence is essential for inflammatory sensitization to noxious thermal stimuli but normal sensation of noxious heat can be detected by alternative mechanisms.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Two gradients are better than one. Cloning and expression of odorant receptors. Target neuron prespecification in the olfactory map of Drosophila
- Abstracts: Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
- Abstracts: Henry Salt and 100 years of animal rights. Wildlife ballot initiatives pass in two states. Why they quit: thoughts from ex-hunters
- Abstracts: Clutch desertion and re-nesting in pied flycatchers: an experiment with progressive clutch removal. Migratory orientation of pied flycatchers: interaction of stellar and magnetic information during ontogeny
- Abstracts: Competition and the death of science. Endless ripples on the sands of time. Inquiry into misconduct excoriates Michigan State