Glutamate locally activates dendritic outputs of thalamic interneurons
Article Abstract:
Activation of metabotropic glutamate receptors (mGluRs) on F2 terminals is responsible for most or all of the tetrodotoxin-insensitive increase in spontaneous inhibitory postsynaptic currents observed in lateral geniculate nucleus (LGN) neurons. The activation of mGluRs evokes GABA response and produces inhibitory activity in LGN relay cells. This finding backs up evidence indicating dense localization of mGluRs on F2 but not F1 terminals in the cat LGN. It appears that activating F2 terminals synaptically has effects that are very electronically distant from the cell's soma and axon hillock.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Phantom sensations generated by thalamic microstimulation
Article Abstract:
Thalamic neuronal responses and stimulation-induced sensations have been investigated in six patients with postamputation pain in order to identify the thalamic mechanisms on which phantom sensations in amputees are based. It was found that stimulation in the thalamus in amputees suffering phantom sensations can still recreate sensations of the missing limb, even a very long time after loss of input from the limb. It is clear that the thalamic representation of the amputated limb remains functional.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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