Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons
Article Abstract:
Chemical signalling between neurons is required for rapid information transfer within the brain. Synaptically released glutamate also acts on metabotropic receptors to excite neurons. A unique inhibitory postsynaptic potential (IPSP), mediated by metabotropic glutamate receptor activation, is reported. Calcium from caffeine/ryanodine-sensitive stores was mobilized by activation of metabotropic glutamate receptors (mGluR1), and apamin-sensitive potassium conductance was increased.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
Article Abstract:
A subtype-specific antibody localizes the D4 subtype dopamine-receptor in GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, substantia nigra and globus pallidus. A subset of cortical pyramidal cells also contains the receptors. The D4-controlled GABA modulation helps in targeting clozapine which is effective in the treatment of schizophrenia. Direct and indirect effects on pyramidal cell firing affect the action of clozapine
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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D2 dopamine receptors and personality traits
Article Abstract:
The density of D2 dopamine receptors in the brain is correlated with a detached personality, which is characterized by lack of closeness and warmth in personal relations. However, it remains to be known whether individual variability in D2-dopamine-receptor density is genetically determined or subject to environmental factors. Neuroreceptor density can be a useful biochemical measure for relating genetics to human personality traits.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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