Growth through learning
Article Abstract:
Neural connections in the brain are said to be made, broken and adjusted in strength during an adult's learning process and during development because of long-term potentiation (LTP) and depression. The brain wires itself and refines connections in the primary sensory cortical areas to a very precise state manifested as unsupervised learning in the early stages of life. The question of whether the same cellular machinery responsible for LTP in the hippocampus carries out plasticity in cortical synapses during this period is raised.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Modulation of A-type potassium channels by a family of calcium sensors
Article Abstract:
Rapidly inactivating (A-type) voltage gated potassium (Kv) currents operate in the brain and heart at subthreshold membrane potentials, controlling the excitability of neurons and cardiac myocytes. Three Kv channel-interacting proteins (KChIPs) are described that bind to the cytoplasmic amino termini of Kv4 alpha-subunits. Expression of KChIP and Kv4 form certain features of native A-type currents through modulation of the density, rate of recovery and inactivation kinetics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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A neuronal analogue of state-dependent learning
Article Abstract:
A neuronal analogue of state-dependent learning where cortical neurons exhibit an acetylcholine-dependent expression of an acetylcholine-induced functional plasticity is described. The demonstration on neurons of rate somatosensory 'barrel' cortex was modified to the temporal frequency of whisker deflections by cellular conditioning. Frequency-specific changes in response were observed following administration of acetylcholine.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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