High intrinsic rate of DNA loss in Drosophila
Article Abstract:
Phylogenetic analysis of a non-long terminal repeat element, Helena, shows that the copies of retransposable elements lose DNA at a high rate. This suggests that the lack of pseudogenes in Drosophila is due to deletion of DNA in the unconstrained regions. The absence of pseudogenes poses a problem for the estimation of patterns of neutral DNA changes. The deletion and insertion of pseudogenes affects the functional genes, which need to be purified. This study helps in the analysis of genome evolution and the C-value paradox.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Regions of variant histone His2AvD required for Drosophila development
Article Abstract:
It has been possible to identify regions that play a significant part in the specificity of function of H2AZ, a variant of the histone protein H2A which is needed for the survival of Drosophila melanogaster. It was established that the unique feature of Drosophila H2AZ lies in its carboxy-terminal domain, rather than its histone fold. The C-terminal region maps to a short alpha-helix in H2A situated deep inside the nucleosome core.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
Article Abstract:
Wingless (Wg) is part of the Wnt family of growth factors, and responses to Wg are shown to require cell-surface heparan sulphate in Drosophila. It is shown that the protein encoded by the division abnormally delayed (dally) gene is a cell-surface heparan-sulphate-modified proteoglycan. Dally is also shown to have tissue-specific effects on Wg and Dpp signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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