Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli
Article Abstract:
Research describing the characteristics of cyclic-nucleotide-gated channels activated by hyperpolarization is presented. Particular attention is given to identification of currents activated by hyperpolarization and to processes of immunohistochemistry.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Independent evolution of bitter-taste sensitivity in humans and chimpanzees
Article Abstract:
The study shows that phenylthiocarbamide (PTC) taste sensitivity in chimpanzees is also controlled by two common alleles of TAS2R38, however, neither of these alleles is shared with humans. Instead, a mutation of the initiation codon results in the use of an alternative downstream start codon and production of a truncated receptor variant that fails to respond to PTC in vitro.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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A TAS1R receptor-based explanation of sweet 'water-taste'
Article Abstract:
A sweet 'water-taste', which is elicited when sweet-taste inhibitors are rinsed away is studied. It is observed that response of cultured cell expressing the human sweetener receptor directly parallel the psychophysical responses-water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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