Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
Article Abstract:
A small inversion within chromosome 2p has resulted in the formation of a fusion gene comprising proteins of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells. The results have shown that a subset of NSCLC proteins have expressed a transforming fusion kinase, which might be a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
A microtubule-binding myosin required for nuclear anchoring and spindle assembly
Article Abstract:
The Xenopus laevis myosin-10 (Myo10) that associates with microtubules in vitro and in vivo, and is concentrated at the point where the meiotic spindle contacts the F-actin-rich cortex is presented. The results as well as demonstrations showing that other unconventional myosins can associate with microtubules indirectly or directly suggest that myosin has a novel and critically important role during meiosis in integrating the F-actin and microtubule cytoskeletons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Fission yeast mod5p regulates polarized growth through anchoring of tea 1p at cell tips
Article Abstract:
The tea1p and mod5p act in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Its various consequences are detailed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Adaptation of core mechanisms to generate cell polarity
- Abstracts: Coherent quantum control of two-photon transitions by a femtosecond laser pulse. Discretizing light behaviour in linear and nonlinear waveguide lattices
- Abstracts: Genetic modification of heterochromatic association and nuclear organization in Drosophila. Versatile assembler
- Abstracts: Production and evolution of light elements in active star-forming regions. Dodecahedral space topology as an explanation for weak wide-angle temperature correlations in the cosmic microwave background
- Abstracts: Functional impact of syntaxin on gating of N-type and Q-type calcium channels. The role of neuronal identity in synaptic competition