Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
Article Abstract:
Many dispersed germline V segments must undergo recombination following D-J segment joining to generate the full diversity of antibody heavy-chain genes. The process is reported to be controlled by the alpha-chain of the receptor for interleukin-7, a cytokine stimulating B-cell lymphopoiesis. Ligands of the interleukin-7 receptor provide an extrinsic signal targeting the V-segment recombination in the heavy-chain locus by changing DNA substrate accessibility.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Identification and expansion of human colon-cancer-initiating cells
Article Abstract:
The tumorigenic potential of colon [CD133.sup.+] cell is evaluated by comparing the ability of tumor-derived [CD133.sup.+] and [CD133.sup.-] cells to engraft and give rise to subcutaneous tumors in severe combined immunodeficient (SCID) mice. The analysis has suggested that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic [CD133.sup.+] cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Aborting the birth of cancer
Article Abstract:
The findings of a study shows that oncogene-driven cell-division cycles trigger DNA damage associated with DNA replication, and this DNA damage raises a barrier to the sustained proliferation of the caner cells. It suggests that for the progression toward full-blown cancer requires the wayward cell to inactivate the mechanisms that monitor damage during DNA replication.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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