Imprinted expression of the Igf2r gene depends on an intronic CpG island
Article Abstract:
Mouse transgenes can be used to investigate the role of region 2, a region with many cytosine-guanine doublets in the second intron of the mouse Igf2r gene, and the influence of chromosome location on Igf2r imprinting. The imprinted methylation and expression pattern of the endogenous Igf2r gene were reproduced with yeast artificial chromosome transgenes. It was established that repression of the Igf2r promoter can be relieved by delection of region 2. This finding has links with the de-repression of Igf2 and insulin following deletion of the H19 gene.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Bone and haematopoietic defects in mice lacking c-fos
Article Abstract:
The c-fos protein, a major component of the AP-1 transcription factor complex, is not simply a general regulator of cell proliferation. Experiments with transgenic mice show that c-fos has a specific function in the development of cartilage, bone and hematopoietic cells. This essential molecule cannot be substituted by other components of the AP-1 transcription factor complex. Fos -/- mice show retarded growth, altered hematopoiesis and deficient tooth eruption and bone remodeling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Psoriasis-like skin disease and arthritis caused by induced epidermal deletion of Jun proteins
Article Abstract:
A study reports that in psoriatic lesions, inflammatory disease of skin and joints, epidermal keratinocytes have decreased expression of JunB, a gene localized in the psoriasis susceptibility region PSORS6. Inducible epidermal deletion of JunB and its functional comparison c-Jun in adult mice leads to a phenotype resembling the histological and molecular hallmarks of psoriasis, including arthritic lesions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Relationship between asymmetric nodal expression and the direction of embryonic turning. An LDL-receptor-related protein mediates Wnt signalling in mice
- Abstracts: Transgenerational induction of defences in animals and plants. The impact of ultraviolet radiation on the vertical distribution of zooplankton of the genus Daphnia
- Abstracts: Molecular cloning and overexpression of the human FK506-binding protein FKBP. Regulatory intramolecular association in a tyrosine kinase of the Tec family
- Abstracts: p53, guardian of the genome. A death in the life of p53. Checkpoint policing by p53
- Abstracts: Ice-age atmospheric concentration of nitrous oxide from an Antarctic ice core. Merely the tip of the ice core