In vivo enhancer analysis of human conserved non-coding sequences
Article Abstract:
The extreme evolutionary sequence conservation is used as a filter to identify putative gene regulatory elements and the in vivo enhancer activity of a large group of non-coding elements in the human genome that are conserved in human-rat-mouse is characterized. The results have illustrated the utility of the training sets for a variety of biological applications, including decoding the regulatory vocabulary of the human genome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A RNA gene expressed during cortical development evolved rapidly in humans
Article Abstract:
A ranking of regions in the human that show significant evolutionary acceleration is devised. A report that the most dramatic of these 'human accelerated region', HAR1, is part of a novel RNA gene (HAR1F) that is expressed specifically in Cajal-Retzius neurons in the developing human neocortex from 7 to 19 gestational weeks, a crucial period for cortical neuron specification and migration is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A distal enhancer and an ultraconserved exon are derived from a novel retroposon
Article Abstract:
A study to show that distal enhancer and an ultraconserved exon are derived from a novel retroposon is presented. Relics of transposable elements have acquired a function that serves their host, a process termed 'exaptation', and provide an origin for at least some of the many highly conserved vertebrate-specific genomic sequences.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Landscape analysis of northern goshawk breeding home range in northern Japan. Riparian and upland breeding-bird assemblages along headwater streams in Michigan's Upper Peninsula
- Abstracts: Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Structural basis for template-independant RNA polymerization
- Abstracts: Effectiveness of Environmental Cluster Analysis in Representing Regional Species Diversity. Appreciating Ecological Complexity: Habitat Contours as a Conceptual Landscape Model
- Abstracts: DNA sequence and analysis of human chromosome 8. Analysis of the DNA sequence and duplication history of human chromosome 15
- Abstracts: Nesting habitat characteristics of the marbled murrelet in central California redwood forests. Local survival of marbled murrelets in Central California: role of oceanographic processes, sex and radiotagging