Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Article Abstract:
Huntington's disease (HD), a neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion within the protein huntingtin (Htt), is characterized by the aggregation of Htt into microscopic intracellular deposits called inclusion bodies (IBs) and by the death of striatal and cortical neurons. When multiple effectors mediate pathogenesis, survival analysis provides a way to quantify the contribution of each factor, potentially helping to assess its individual pathogenic significance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Coevolution with viruses drives the evolution of bacterial mutation rates
Article Abstract:
The article explains that the coevolution with viruses drives the evolution of bacterial mutation rates in the bacterium, Pseudomonas fluorescens. The results prove that the bacteriophages play a very important role in the evolution of bacterial mutation rates.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Toxic alert
Article Abstract:
Researchers are worried about the potential toxicity of the recombinase 'Cre' expression to cells. The Cre enzyme is a good technique that allows the introduction of mutations and gene deletions in a tissue or cell type at any stage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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