Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
Article Abstract:
The regulation of Drosophila wing formation and identity by the vestigial (vg) gene involves integration of positional signals and regulation of the activity of two enhancers. The enhancer in the second intron is stimulated during the early developmental stages by the dorsoventral (D/V) signal pathway. The enhancer in the fourth intron is stimulated by signals from the D/V boundary and the anteroposterior axis during the later developmental stages. The phenotype of vg mutants and regulation of vg activity are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Drosophila Mad binds to DNA and directly mediates activation of vestigial by decapentaplegic
Article Abstract:
Growth and pattering of several structures are affected by the transforming growth factor-beta (TGF-beta)-related signalling proteins such as Decapentaplegic (Dpp) in Drosophila. A study shows that the Drosophila Mothers against dpp protein (Mad) binds to and is needed to activate an enhancer in the vestigial wing genes in cells throughout the wing blade. It also binds to other Dpp-response elements and the results indicated that gene expression is regulated by activating the Mad binding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Fringe forms a complex with Notch
Article Abstract:
A new study shows that the Fringe protein of Drosophila forms a complex with Notch through both the epidermal growth factor repeats 22-36 and the Lin-Notch repeats of Notch when they are co-expressed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Integrating economics into priority setting and evaluation in conservation management. Distribution of carabid beetles (Coleoptera, Carabidae) across a boreal forest - clearcut ecotone
- Abstracts: Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
- Abstracts: Transformation of spin information into large electrical signals using carbon nanotubes. A single type of progenitor cell maintains normal epidermis
- Abstracts: Control of protein-ligand recognition using a stimuli-responsive polymer. Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield
- Abstracts: Big rigs in blood coagulation. Not just an active site. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor