Intracellular action of the cytokine MIF to modulate activity and the cell cycle through Jab1
Article Abstract:
Research into the interaction of the cytokine macrophage migration inhibitory factor (MIF) with the intracellular protein Jab1 is presented. MIF is shown to negatively regulate pathways controlled by Jab1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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MIF as a glucocorticoid-induced modulator of cytokine production
Article Abstract:
The migration inhibitory factor (MIF) is an important constituent of the immune system that acts in coordination with glucocorticoids to control inflammation and immunity. Glucocorticoids in low levels can induce MIF in macrophages. MIF overcomes the action of glucocorticoids in the production of lipopoly-saccharide that stimulates the formation of monocytes. Although it was known that glucocorticoids are necessary for the regulation of immune responses, the endogenous mediators of their activity were unknown.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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An agent cleaving glucose-derived protein crosslinks in vitro and in vivo
Article Abstract:
N-phenacylthiazolium bromide (PTB) effectively cleaves the crosslinks formed between protein amino acids and advanced-glycation end-products (AGEs) during the reaction of collagen with AGE-modified bovine serum albumin. PTB also cleaves crosslinks in tail tendons of diabetic rats and brain tissues of Alzheimer's disease patients. The cleaving ability of PTB indicates that the crosslinks contain an alpha-diketone. Thiazolium compounds such as PTB may be of clinical importance by removing established AGE crosslinking which may ameliorate tissue pathology.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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