Intracellular pattern recognition receptors in the host response
Article Abstract:
The innate immune system of a host organism, which rapidly detects invading pathogenic microbes as foreign and eliminates them, are based on a small number of receptors called pattern recognition receptors (PRRs). Toll-like receptors (TLR), a class of PRRs, are membrane receptors that sense extracellular microbes or membrane-enclosed foreign organisms and trigger anti-pathogen signaling cascades to protect the host.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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IKK alpha controls formation of the epidermis independently of NF-kB
Article Abstract:
Research is presented describing the role of IKKalpha in the formation of the epidermis. IKKalpha is vital for developing the epidermis and its derivatives. Research shows that keratinocyte differentiation is induced by a soluble factor, the production of which is controlled by IKKalpha differentiation, with the differentiation not controlled through NF-kB.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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