LKB1 modulates lung cancer differentiation and metastasis

Article Abstract:

A somatically activatable mutant Kras-driven model of mouse lung cancer is used to compare the role of germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) to other tumor suppressors in lung cancer. The analysis has shown LKB1 as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis.

Models, Gene mutations, Gene mutation, Tumor suppressor genes, Lung cancer, Tumour suppressor genes

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

Article Abstract:

The hypothesis on tumorigenesis is tested by transiently blocking cytokinesis in p53-null mouse mammary epithelila cells (MMECs), enabling the isolation of diploid and tetraploid cultures. The tetraploid cells had an increase in the frequency of whole chromosome mis-segregation and chromosomal rearrangements.

Immunofluorescence, Fluorescent antibody technique, Epithelial tumors, Cytokinesis, Epithelial tumours

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Genome-wide genetic analysis of polyploidy in yeast

Article Abstract:

A genome-wide screen to identify ploidy-specific lethal functions is reported. It is observed that geometric constraints have profound effects on genome stability relevant in a variety of biological contexts, including disease states such as cancer.

Colorado, Genetic aspects, Growth, DNA damage, Genomes, Yeast fungi, Yeasts (Fungi), Polyploidy, Company growth

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