MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus
Article Abstract:
Both mesenchymal cells and major histocompatibility complex class II+ epithelial cells are needed to effect the growth of T-cells in the thymic stroma. In vitro testing of the factors necessary for T-cell development in the thymus showed that both types of cells and fibroblasts are essential. The mesenchyme's influence is probably confined to one stage of T-cell development and is incapable of acting without other cellular interactions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
Article Abstract:
A clonal assay to investigate the developmental potential of single, individually selected, thymic epithelial progenitors developing within the normal architecture of the thymus is presented. The findings, which resolve a long-standing issue in thymus development, have important implications for development of cell-based strategies for thymus disorders and the possibility of restoring function of the atrophied adult thymus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
Article Abstract:
The prospect of deriving cortical and medullary epithelial cell type form one common progenitor and the existence of such cells in postnatal thymus tissue are studied. Results of in vivo cell lineage analysis in mice demonstrate that single epithelial progenitor cells could give rise to a complete and functional thymic microenvironment, in turn leading to the development of cell-based therapies for thymus disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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