Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
Article Abstract:
A demonstration that Sleeping Beauty (SB), a member of the Tc1/mariner class of transposons, could be mobilized in mouse somatic cells at frequencies high enough to induce embryonic death and cancer in wild-type mice is presented. SB transposition could easily be controlled to mutagenize any target tissue and could therefore, in principle, be used to induce many of the cancers affecting humans, including those for which little is known about the aetiology.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Direct interaction of microtubule- and actin-based transport motors
Article Abstract:
The microtubule network is believed to be used for cellular component transport over a long range in animal cells. The actin network is though to be used for transport over a short range. The actin-based vesicle-transport motor MyoVA is shown to interact with the microtubule-based transport motor, KhcU. This suggests that cellular transport is partly coordinated via direction interaction of different motor molecules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
Article Abstract:
The ability of the Sleeping Beauty transposon is reported to act as a somatic insertional mutagen to identify genes involved in solid tumour formation. A Sleeping Beauty transposon, engineered to elicit loss-of-function or gain-of-function mutations, transposed in all somatic tissues tested and accelerated tumour formation in mice predisposed to cancer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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