Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1
Article Abstract:
Herpes simplex virus type-1 (HSV-1) causes infections of the skin and the nervous system. HSV-1 can cause blisters on the skin and mucous membranes in the facial area, especially in the mouth and nose. It is known that the virus uses a cellular receptor for basic fibroblast growth factor (FGF) to bind with and enter into the host cell. However, the mechanism of binding is not understood. A protein that is similar to the basic FGF protein, and is associated with the virus, has been identified. However, the HSV-1 virus does not contain genes that encode a basic FGF protein. Therefore, the virus cannot synthesize this protein. It is thought that the virus uses basic FGF obtained from the host cell. The cellular response of infection with HSV-1 involves the addition of phosphate molecules to the amino acid tyrosine. This cellular response also occurs with the addition of basic FGF. The addition of antibody molecules against basic FGF to cells causes blockage of the receptor and prevents phosphorylation of tyrosine molecules. Therefore, entry of HSV-1 into cells is inhibited. The identification of the mechanism of how the virus enters into the cell is important for the developing ways of preventing or treating infection with HSV-1. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1990
User Contributions:
Comment about this article or add new information about this topic:
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Article Abstract:
Vascular endothelial growth factor (VEGF), also called vascular permeability factor, may induce the growth of new blood vessels (angiogenesis or neovascularization) as the body's response to hypoxia or the lack of oxygen. Glioblastoma multiforme (gm), a malignant human brain tumor, was used to assess the effect of VEGF since tumors often cause angiogenesis. The rise in VEGF messenger RNA quantities shortly after the start of gm-induced hypoxia bore out the hypothesized link between VEGF and angiogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Growth factor function of vasoactive intestinal peptide in whole cultured mouse embryos
Article Abstract:
The potential effects of the vasoactive intestinal peptide (VIP) on embryonic growth was investigated. VIP stimulated growth in whole postimplantation embryo cultures after incubation for four hours. Increase in somite nuber, embryonic volume, DNA and protein content and number of cells in S-phase was also observed. The findings suggest that VIP acts as a growth factor on early postimplantation embryos through multiple VIP receptors that exhibit tissue-specific responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Simulation of defect nucleation in a crystal. Prediction of absolute crystal-nucleation rate in hard-sphere colloids
- Abstracts: Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins
- Abstracts: Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Cell-free activation of a DNA-binding protein by epidermal growth factor
- Abstracts: Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Parental-origin-specific epigenetic modification of the mouse H19 gene
- Abstracts: Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin