Mesoderm induction in zebrafish
Article Abstract:
Mesoderm induction in zebrafish takes place through the passage of signals from the yolk cell to the syncytial layer and finally to the blastoderm cells. The localized inducing activity in the yolk cell influences the dorsal tissue, and histological examination reveals the localization of ectopic expression in a region that bears little relationship to the host dorsal region. The teleost yolk cell is similar to the vegetal endodermal cell mass in the amphibian Xenopus, and the basic mechanism of mesoderm formation is probably conserved between the teleosts and the amphibia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
Article Abstract:
Zebrafish cyclops (cyc) mutations lead to deficiencies in the dorsal mesendoderm and ventral neural tube, resulting in neural defects and cyclopia. It is reported that cyc encodes a transforming growth factor-beta (TGF-beta) related intercellular signalling molecule, similar to mouse nodal. Sonic hedgehog-expressing cells of the ventral brain and floorplate are restored with injection of cyc RNA. It is suggested that cyc offers an important non-cell-autonomous signal at gastrulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
Article Abstract:
Somites are precursors of adult skeletal muscle, bone and cartilage, and somite progenitor cells ingress through the primitive streak during embryogenesis, moving to a paraxial position. The embryonic pattern of expression of the mouse T-box gene Tbx6 in somite precursor cells, indicate that the gene may be involved in paraxial mesoderm specification. A mutation in Tbx6 was creation that profoundly affects paraxial mesoderm differentiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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