Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
Article Abstract:
Serum paraoxonase (PON1) is an esterase linked with high-density lipoproteins (HDLs) in plasma, involved in detoxification of organophosphate insecticides. The role of PON1 was studied in vivo, with the creation of PON1-knockout mice by gene targeting. PON1-deficient mice were sensitive to chlorpyrifos oxon toxicity, and HDLs isolated from them could not prevent low-density lipoprotein oxidation. PON1-null mice became more susceptible to atherosclerosis when fed on a high fat, high cholesterol diet, than wild type littermates.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Out from the haze
Article Abstract:
The controversies arising from the ban on smoking in enclosed public places and the link between second hand smoke and heart disease is explained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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