Mitotic spindle organization by a plus-end-directed microtubule motor
Article Abstract:
The dynamic self-organization of spindle poles in mitosis may require kinesin-related motor proteins such as Eg5 derived from Xenopus eggs. In vitro assays for spindle assembly involving Eg5 found that the immunodepletion of this protein influenced spindle formation. In addition, Eg5 was identified as a plus-end-directed microtubule motor protein. These results clarify the role of microtubule motor proteins in cell division and mitosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Poly(ADP-ribose) is required for spindle assembly and structure
Article Abstract:
The study reported that Poly(ADP-ribose) (PAR) is enriched in the spindle required for spindle function, PAR hydrolysis or perturbation leads to rapid disruption of spindle structure, and hydrolysis during spindle assembly blocks the formation of bipolar spindles. It concluded that PAR is a non-proteinaceous, non-chromosomal component of the spindle required for bipolar spindle assembly and function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Experimental and theoretical study of mitotic spindle orientation
Article Abstract:
Spindle orientation is understood as a result of the action of cortical force generators, which has interacted with spindle microtubules and is activated by cortical cues. A simple model is developed that has described asymmetric spindle orientations and has provided a quantitative description of the spindle orientation of adherent cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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