Modulation of GABA(sub A) receptors by tyrosine phosphorylation
Article Abstract:
Tyrosine phosphorylation is inhibited by mutations in tyrosine residues in the intracellular region of the gamma-2-L subunit of gamma-aminobutyric acid type-A (GABA-A), similar to regulation of GABA-A in neuronal cultures, indicating that the modulation of tyrosine kinase probably affects neuronal excitation. Phosphorylation of tyrosine accelerates the whole-cell current stimulated by GABA and GABA-A receptors are crucial in acting as intermediaries in fast synaptic inhibition.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Bidirectional control of CNS capillary diameter by pericytes
Article Abstract:
A study was conducted to show that pericytes which are apposed to central nervous system (CNS) capillaries and contain contractile proteins could control capillary diameter in whole retina and cerebellar slices. The results suggest that pericytes are probably modulators of blood flow in response to changes in neural activity, which might contribute to functional imaging signals and to CNS vascular disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Tolerance: a second mechanism
- Abstracts: Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. part 2 V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
- Abstracts: Elongation factor-1-alpha gene determines susceptibility to transformation. A kinase from fission yeast responsible for blocking mitosis in S phase
- Abstracts: Identification of a galaxy responsible for a high-redshift Lyman-alpha absorption system. The O/C abundance ratio in absorbing gas clouds at high redshift
- Abstracts: Production of sperm reduces nematode lifespan. A message from the gonads. Regulation of lifespan by sensory perception in Caenorhabditis elegans