Movement and force produced by a single myosin head
Article Abstract:
A single-headed myosin subfragment-1 (S1) causes movement and force in muscles. An optical-tweezers transducer is used to analyze the interaction between S1 and actin which is responsible for such mechanical events. This mechanism is similar in displacement and force to that of heavy meromyosin (HMM). For a single acto-S1 interaction, the working stroke size is about 4 nanometers. At isometric conditions, S1 or heavy meromyosin produces an average force of 1.7 pN.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A type VII myosin encoded by the mouse deafness gene shaker-1
Article Abstract:
Analysis of the mouse shaker-1 (sh1) gene indicates that this gene encodes a type VII myosin molecule, mutations in which lead to impaired hearing and subsequent deafness. A mutation in the splice acceptor site and two missense mutations cause this genetic defect in auditory transduction. Organ of Corti degeneration and cochlear and vestibular defects are symptomatic of this disorder.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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The core of the motor domain determines the direction of myosin movement
Article Abstract:
It has been possible to establish the direction of motility of chimaeric myosins that make up the motor domain and the lever-arm domain from myosins that have movement in the opposite direction. The direction of myosin movement is controlled by the motor core domain, rather than the converter domain or the large class VI myosin-specific insert.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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