Message in a bottle
Article Abstract:
Applying what is known about the mutation rates of bacterial populations to the forecasting of prevalence of human genetic disorders is the subject of an important article by J. Hastbacka and coworkers in the Nov 1992 Nature Genetics. The authors derive their approach from the 1943 research of Salavador Luria and Max Delbruck on the spontaneous occurrence of bacterial mutation. Hastbacka and colleagues have analysed the rates of genetic disorders in Finland and conclude that inherited human conditions such as diastrophic dysplasia may also arise unpredictably.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Diabetes defect defined
Article Abstract:
Identification of the mutations underlying nephrogenic diabetes insipidus (NDI) made significant progress as indicated by two articles in the Oct 1992 Nature Genetics announcing that two research groups have discovered nine new mutations linked to NDI. The defect that causes NDI, an X-linked recessive disorder, is thought to be located located in the vasopressin V2 receptor. Bernard van Oost and colleagues found three V2 receptor mutations while Jane Gitschier and colleagues found six mutations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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