Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Article Abstract:
The VKOR complex is analyzed in two heritable human diseases: combined deficiency of vitamin-K-dependent clotting factors type 2 (VKCFD2: Online Mendelian Inheritance in Man (OMIM) 607473), and resistance to coumarin-type anticoagulant drugs (warfarin resistance, WR; OMIM 122700) using linkage information from three species.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Identification of the gene for vitamin K epoxide reductase
Article Abstract:
Identification of the gene for vitamin K epoxide reductase (VKOR) is reported based on specific inhibition of VKOR activity by a single siRNA pool. It is confirmed that MGC11276 messenger RNA encodes VKOR through its expression in insect cells and sensitivity to warfarin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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K is for koagulation
Article Abstract:
The importance of vitamins in medical and economic fields in the light of vitamin K is discussed. The key component of vitamin K metabolism in comparative genetic linkage studies in rats, mice and humans is identified.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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