Myc deletion rescues Apc deficiency in the small intestine

Article Abstract:

A demonstration that loss of Myc rescued the phenotypes of perturbed differentiation, migration, proliferation and apoptosis, which occur on deletion of Apc, is presented. Findings reveal that Myc is required for the majority of Wnt target gene activation following Apc loss, establishing Myc as the critical mediator of the early stages of neoplasia following Apc loss.

United States, Genetic aspects, Phenotype, Phenotypes, Oncogenes, Adenoviruses, Human, Human adenoviruses, Intestine, Small, Small intestine

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Notch/gamma -secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Article Abstract:

Maintenance of undifferentiated, proliferative cells in crypts and adenomas requires the concerted activation of the Notch and Wnt cascades. The data indicate that gamma-secretase benefit in colorectal neoplastic disease.

Colorectal cancer

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Notch signals control the fate immature progenitor cells in the intestine

Article Abstract:

The study describes the involvement of Notch in intestinal development. The conclusion indicates that Notch activity is required for the maintenance of proliferating crypt cells in the intestinal epithelium.

Observations

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