Ignore the nonsense
Article Abstract:
A small organic molecule, PTC124, has forced the translation machinery to ignore the premature termination codons (PTCs), without preventing it from reading the real stop signals The identification of the molecular target of PTC124 might help in filling the gap between the reductive and the pioneer modes of translation and it might also help in becoming the research tool for evaluating the mechanisms of the termination of protein translation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy:
Article Abstract:
A hypothesis-driven, systems biology approach to identifying a small subset of proteins induced at the tissue-blood interface that are inherently accessible to antibodies injected intravenously is presented. Subcellelular fractionation, subtractive proteomics and bioinformatics are used to identify endothelial cell surface proteins exhibiting restricted tissue distribution and apparent tissue modulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Sheep retrovirus structural protein induces lung tumours
Article Abstract:
A study conducted on the Jaagsiekte sheep retrovirus (JSRV) shows that expression of the JSRV envelope (Env) protein alone in lungs of mice results in tumours with a bronchiolo-alveolar localization like those seen in sheep. The result obtained from the study shows that interaction of the viral Env protein with the virus entry receptor Hyal2 is not required for tumorigenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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