NMDA spikes in basal dendrites of cortical pyramidal neurons
Article Abstract:
Synaptic processing in basal dendrites can be analyzed by identifying fine dendritic branches using fluorescence confocal microscopy and mimicking excitatory postsynaptic potentials by ultraviolet laser glutamate uncaging. It was shown that coactivation of clustered neighbouring basal inputs initiated local dendritic spikes which were accompanied by large calcium transients limited to the activated dendritic segment. N-methyl-D-aspartate spikes could make a unique contribution to synaptic processing.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurones
Article Abstract:
Mammalian neurons have branches of dendrites that receive and integrate sensory signals but, until now, it has been unclear how such inputs are processed. Researchers have found potassium channels in dendrites from hippocampal pyramid neurons. The presence of such channels could explain some questions about dendritic function. The A-type channels could act to counter dendritic polarization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Dendritic shock absorbers
Article Abstract:
Research shows that dendrites of hippocampal pyramidal neurons have potassium channels, which play an important part in dendrite excitability. It is proposed that dendritic A-type potassium channels could control dendritic spiking, leading to a greater inflow of calcium into the dendritic spines, regulated by different parts of the dendritic tree.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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