Neural control of dieting
Article Abstract:
L.H. Tecott and colleagues determined that the 5-hydroxytryptamine neurotransmitter subtype 5-HT(sub 2C) receptor was involved in the satiety response, resulting in obesity when the receptor was not present. This helps in the understanding of why the diet pill dexfenfluramine is successful because it promotes a large release of 5-HT, restoring the balance between 5-HT and its receptors. Dieting causes a reduction in the 5-HT precursor, plasma tryptophan, and increases the 5-HT(sub 2C) receptors' sensitivity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Induction and organization of Ca(super2+) waves by enteric neural reflexes
Article Abstract:
The motility of the gastrointestinal tract comprises local, non-propulsive mixing and propulsive movements. Peristalsis is found to be compromised in mice without interstitial cells of Cajal, indicating that the cells may be involved in neural reflexes. Mixing movements within longitudinal muscle are shown to results from spontaneously generated waves of elevated internal calcium concentrations from discrete locations. The enteric nervous system is found to organize mixing movements to generate peristalsis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Why is dieting so difficult?
Article Abstract:
Cosmetic or medical dieting may be worthless because researchers have discovered that the body's response to a reduced food intake is a reduction in 5-HT2c receptors which generates the behavioral response of overeating. Therefore, dieting may actually cause the reverse effect by creating a biological drive to increase food intake. However, another aspect of this research involves the potential for 5-HT2c receptor manipulation as a method for clinically warranted weight loss.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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