Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
Article Abstract:
It has been possible to identify loss-of-function mutations in the Drosophila Presenilin gene that lead to lethal Notch-like phenotypes. Presenilin has been seen to be needed for the normal proteolytic production of carboxy-terminal Notch fragments that are required for receptor maturation and signalling. The Notch-like phenotypes and altered Notch protein species identified in Drosophila Presenilin mutants indicate a shared mechanism of regulated proteolysis that could be a significant element in both Notch processing and Alzheimer's disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Charting orientation territories
Article Abstract:
Development of orientation selectivity in the visual cortex is determined by the patterns of neural activity. Stimulation of the optic nerve can activate cortical neurons as demonstrated in an experiment conducted by Weliky and Katz. Artificial synchronization of stimuli during the development stages of the visual cortex can disorient the naturally occurring patterns of neural activity resulting in a reduced specificity of orientation and direction of responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis
Article Abstract:
Synaptogenesis or the development of synapses in Drosophila embryos requires the muscle to use preferential adhesion mechanisms to move the motor neurons near the synaptic zone. The motor neurons then prompt the localization of glutamate receptors (gluRs) to the synaptic zone with additional expression of gluRs as the synapses grow. Drosophila and vertebrate synaptogenesis both require the differentiation of the postsynaptic neuromuscular junction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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