Nobel committee rewards pioneers of development studies in fruitflies

Article Abstract:

Three developmental biologists have won the 1995 Nobel Prize for physiology and medicine. The award was given for identifying the role of genes in the early embryonic development of fruitfly (Drosophila melanogaster). The results of the research work can be used to understand the growth patterns in complex organisms. The recognition of biologists may change the attitudes of science policy makers and encourage research in fundamental science.

Achievements and awards, Biologists, Nobel prizes, 1995 AD

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Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

Article Abstract:

Mouse pygmy phenotypes do not result from growth hormone-insulin-like growth factor endocrine pathway aberrations but rather from inactivated Hmgi-c proteins, indicating the proteins' importance in mammalian growth and development. Hmgi-c appears to be a cell-autonomous cell proliferation factor which is essential for the stereospecific transcriptional complexes' assembly while acting as a nuclear scaffold architectural factor.

Genetic aspects, Growth factors, DNA binding proteins, Animal mutation

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