Nuclear organization of the genome and the potential for gene regulation
Article Abstract:
The new data from vertebrates that helps in clarifying the function of genes in the context of the nucleus is discussed and has suggested that the genome's spatial organization is a key contributor to its function. The long-range gene interactions and gene interactions with transcription factors are analyzed emphasizing on the potential of such organization for gene regulation, especially epigenetic regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Structural basis for redox regulation of Yap1 transcription factor localization
Article Abstract:
The redox-regulated domain of Yap1 is identified and its high-resolution solution structure is determined. The results indicate the structural basis of redox-dependent Yap1 localization and provide an unknown mechanism of transcription factor regulation by reversible intramolecular disulphide bond formation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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