Nuclear receptor that identifies a novel retinoic acid response pathway
Article Abstract:
A new receptor present in the nucleus of cells which is similar to the receptors for steroid, or sex hormones has been identified. The receptor binds retinoids, or vitamin A metabolites, which are a group of compounds including retinol (vitamin A), retinoic acid, and a number of natural and synthetic compounds. Vitamin A compounds have a profound effect on the development and differentiation of cells and tissues. Retinoic acid induces the synthesis of several genes, as do the steroid and thyroid hormones. A group of receptors has been previously identified which is dependent on retinoic acid for the activation of genes. However, this newly isolated receptor is different from the retinoic acid receptors which have previously been identified. The identification of this receptor indicates that another pathway may exist through which retinoic acid has its actions. The previously identified retinoic acid receptors were expressed primarily in the developing individual and only in a limited capacity in the adult. This new receptor is strongly expressed in the adult liver, where vitamin A is stored and metabolized. It is also expressed in other tissues, including the kidney and heart. This receptor may be a regulator of vitamin A metabolism. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1990
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Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
Article Abstract:
Peroxisome proliferators and 9-cis retinoic acid control an overlapping set of target genes by forming a heterodimer that stimulates acyl-CoA oxidase gene expression in response to clofibric acid or the retinoid X receptor-alpha ligand. Exposure to both activators at the same time causes a synergistic induction of gene expression. These findings indicate that 9-cis retinoic acid has a physiological function in regulating lipid metabolism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Activation of specific RXR heterodimers by an antagonist of RXR homodimers
Article Abstract:
A new retINNid X receptor (RXR) homodimer antagonist which also acts as an agonist when RXR is paired as a heterodimer to specific partners is identified. The new RXR ligand promotes association with TAF110 and the co-repressor SMRT(super-7), a characteristic which is inconsistent with pure RXR agonists. It can also be used for controlling distinct target genes at the level of transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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