Orientation of DNA replication establishes mating-type switching pattern in S. pombe
Article Abstract:
It has been possible to develop a replication-orientation model that gives an insight into the underlying molecular mechanism for the asymmetric switching pattern of the fission yeast Schizosaccharomyces pombe. It appears that the switching pattern is attributable to a heritable strand-specific imprinting event that changes the strand synthesized only during lagging-strand replication. This is thought to be the first example of the orientation of DNA replication establishing the asymmetric developmental potential of two sister cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Activation of complement by an IgG molecule without a genetic hinge
Article Abstract:
The hinge region of the immunoglobulin G (IgG) molecule need not act as a spacer for complement activation. Its role is apparently to connect the heavy chains in the heavy part of C(H)2, which permits efficient FcR signalling. A hinge-deleted mouse-human chimeric IgG3 molecule with specificity for HM-1 was created. The introduced cysteine in HM-1 forms a disulphide bond linking the molecule's heavy chains. HM-1 showed greater activity then a IgG3 wild type.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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