Restoring function in exhausted CD8 T cells during chronic viral infection

Article Abstract:

Memory CD8 T-cell differentiation proceeds along distinct pathways after an acute versus a chronic viral infection and cells generated after an acute viral infection are highly functional and constitute an important component of protective immunity. The studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections.

Care and treatment, Genetic aspects, CD8 lymphocytes

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Article Abstract:

The role of programmed death 1 (PD-1) in a chronic human viral infection is investigated by examining PD-1 expression on human immunodeficiency virus-(HIV)-specific CD8 T cells in 71 clade-C-infected people who were unaware of anti-HIV treatments, using ten major histocompatibilty complex Class I tetramers specific for frequently targeted epitopes. Results show that PD-1 is significantly upregulated on these cells, and expression correlates with impaired HIV-specific CD8 T cell function as well as predictors of disease progression.

Health aspects, HIV infection, HIV infections, T cells

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