Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
Article Abstract:
Activation of phospholipase C (PLC) is thought to mediate phototransduction in invertebrate microvillar photoreceptors. It is unknown how this results in gating of light-sensitive channels. PLC generates a possible precursor for several polyunsaturated fatty acids, and it is shown that they reversibly activate native light-sensitive channels in Drosophila photoreceptors, and recombinant TRPL channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Visual transduction in Drosophila
Article Abstract:
Research in the fruitfly Drosophila has highlighted many of the molecular strategies that form the basis for the processing of visual signals. A significant challenge for scientists is to determine how defined molecular elements work together to produce a physiological output. Photoreceptors have been seen as preferred systems in working towards this aim.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Dynamic platforms
Article Abstract:
A report explains the role of scaffolding proteins as the dynamic platform for the assembly of molecular signalling complexes. The analysis reveals that these proteins are also useful in promoting the signalling specificity of the complexes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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