Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
Article Abstract:
The concept of vaginal microbicide, the application of inhibitory compounds is evaluated using the rhesus macaque 'high dose' vaginal transmission model with a CCR5-receptor-using simian-human immunodeficiency virus (SHIV-162P3) and three compounds that inhibit different stages of the virus-cell-attachment and entry process. Significant protection is achieved using each compound alone and in combinations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Images from the surfaces of HIV
Article Abstract:
The fate of newly produced HIV particles depend on whether protruding structures, or spikes on their surface can make contact with receptors on white blood cells, especially a subset called CD4 T cells. If the viral spikes, which are tripod-like assemblies, make a contact then genetic material of the virus is injected into the target cell and the viral genome starts dictating events in the cell.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Fc receptor but not complement binding is important in antibody protection against HIV
Article Abstract:
A report on the dramatic decrease in the ability of a broadly neutralizing antibody to protect macaques against SHIV challenge when Fc receptor and complement-binding activities are engineered out of the antibody is presented. Results suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Toll-dependent selection of microbial antigens for presentation by dendritic cells. Gene-specific control of inflammation by TLR-induced chromatin modifications
- Abstracts: Regioselective one-pot protection of carbohydrates. Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
- Abstracts: Fruit production in mature and recently regenerated forests of the Appalachians. A rapid hard-mast index from acorn presence - absence tallies
- Abstracts: Elusive flowering signal pruned of mystery at last. 'Monogamous' vole in love-rat shock
- Abstracts: The collector. His daughter's DNA. Bringing the past to life