Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission
Article Abstract:
Stimulation in the hippocampus of protein kinase C by phorbol-12-myristate-13-acetate improves the flow of current through N-type calcium 2+ ion channels (Ca2+). Increased protein kinase C activity also diminishes the control of Ca2+ exerted by G proteins and the metabotropic glutamate receptor. The findings that excitatory synaptic transmission resembles the control of Ca2+ channels may lead to new methods of managing the fast transmissions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A retrograde step forward
Article Abstract:
Arachidonic acid may act as a retrograde messenger to control the release of glutamate in synapses. Inmaculada Herrero and his colleagues have discovered such a positive-feedback mechanism and identified the presynaptic receptor that activates protein kinase C. These processes are involved in learning and memory, and glutamate is the common neurotransmitter in mammalian brains.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system
Article Abstract:
Rapid retrograde synaptic modification also exists in an intact developing retinotectal system. Local application of brain-derived neurotrophic factor(BDNF) leads to a rapid modification of synaptic inputs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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