Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
Article Abstract:
Activation of mitogen-activated protein (MAP) kinase by nerve growth factor has been shown to involve two distinct pathways. The small G protein Ras is needed for the initial activation of MAP kinase, but its activation is sustained by the small G protein Rap1. Nerve growth factor may use CRK isoforms to activate Ras as well, as Ras activation by nerve growth factor can be blocked by interfering mutants of CRK. The regulation of B-Raf expression in tissues could provide a new mechanism for modulating growth factor signalling by Rap1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Distinct ATP receptors on pain-sensing and stretch-sensing neurons
Article Abstract:
Cytoplasmic components acting upon nociceptors, or pain sensors, may cause the initial pain from tissue damage. ATP may be active in cytoplasmic fractions that cause pain, and its contribution to nociception was tested via a tissue culture system, enabling the comparison of noicecptive and non-nociceptive rat sensory neurons. The hypothesis that ATP acting through P2X3 receptors will activate nociceptors following local tissue damage is supported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A local route to pain relief
Article Abstract:
Researchers have provided a new approach to analgesia, which is used for stopping pain. They have shown that administering a mix of QX-314, a charged local anesthetic, and capsaicin has shut pain sensation without affecting any other nerve responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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