MAD2haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
Article Abstract:
The deletion of one MAD2 allele causes a defective mitotic checkpoint in human cancer cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
Article Abstract:
A study is conducted to show that the mitotic checkpoint protein Mad2 is a direct E2F target and, as a consequence, is aberrantly expressed in cells with retinoblastoma (Rb) pathway defects. The results show how chromosome instability can arise as a byproduct of defects in cell cycle control that compromise the accuracy of mitosis, and also suggest a new model to explain the frequent appearance of aneuploidy in human cancer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
Article Abstract:
It has been established that Id1 or Id3 expression is needed for maintaining the timing of neuronal differentiation and proper angiogenesis in the neuroectoderm during mouse development. Partial reduction in Id dosage was found to lead to an angiogenic defect in adult mice which hampers the vascularization, growth and metastasis of tumour xenografts. The premature neuronal differentiation of Id1-Id3 double knockout mice suggests that Id1 or Id3 is needed to block the exactly timed expression and activation of positively acting basic helix-loop-helix proteins during murine development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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