Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors
Article Abstract:
A description of a structure of a Ser 2-phosphorylated carboxy-terminal domain (CTD) peptide bound to the conserved CTD-interacting domain (CID) of Pcf11, which is a protein, an essential and evolutionary conserved factor for polyadenylation-dependent is presented. Distinct CTD phosphorylation patterns couple different phases of the transcription cycle to the corresponding RNA-processing events as well as dephosphorylating CTD after or during transcription resulting in Pol II recycling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Molecular basis of RNA-dependent RNA polymerase II activity
Article Abstract:
The molecular and the catalytic activities of the RNA-dependent RNA polymerase II (RdRP) are explained. The RdRP activity is found to be much slower than the DNA-dependent activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Extending the message
Article Abstract:
An attempt is made to provide structural insight into the process of gene transcription, which is the first step in decoding information.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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