Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon-1 subunit
Article Abstract:
Considerable reduction of the N-methyl-D-aspartate (NMDA) receptor channel current occurs when the mouse epsilon-1 subunit gene is subjected to targeted disruption. The targeted disruption also results in long-term potentiation at the hippocampal CA1 synapses. The NMDA receptor channel is involved in synaptic plasticity and helps maintain the process of memory, learning and development in mice and other higher-order animals. The targeted disruption causes a deficiency in spatial learning.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Interaction with the NMDA receptor locks CaMKII in an active conformation
Article Abstract:
It has been established that regulated calcium- and calmodulin-dependent protein kinase II interaction with two sites on the N-methyl-D-aspartate receptor subunit NR2B gives a mechanism for the glutamate-prompted translocation of the kinase to the synapse in hippocampal neurons. This interaction can given rise to further forms of potentiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Global changes to the ubiquitin system in Huntington's disease
Article Abstract:
A mass-spectrometry-based method is used for studying polyubiquitin chains and has shown that the abundance of these chains is a faithful endogenous biomarker of ubiquitin-proteasome system (UPS) function. Huntington's disease (HD) is shown to be linked to global changes in the ubiquitin system to a very large extent.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Sperm and mammalian polarity
- Abstracts: The mahogany protein is a receptor involved in suppression of obesity. The missing link with obesity?
- Abstracts: Hyperacute directional hearing in a microscale auditory system. In a fly's ear
- Abstracts: The octadecanoid signalling pathway in plants mediates a response to ultraviolet radiation. Night moves of pregnant moths
- Abstracts: Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha(sub 1) subunit. Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem