Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha(sub 1) subunit
Article Abstract:
Crosstalk between second messenger pathways is examined. It is shown that this effect can be observed at the level of the presynaptic Ca(2+)-channel complex. The protein kinase C (PKC)-dependent upregulation of calcium channel activity is found to be affected by the alpha(sub 1) subunit domain of I-II linker. Meanwhile, binding of G beta gamma to two sites in the I-II linker is shown to facilitate G-protein-dependent inhibition. Evidence indicates that the PKC-dependent phosphorylation of one of these two G beta gamma binding sites, which resist inhibition induced by G beta gamma, generates crosstalk.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels
Article Abstract:
The patch-clamp technique was applied to test whether calcium current is regulated by G proteins in a vertebrate presynaptic nerve terminal. It was also investigated whether the linkage to syntaxin has an impact on such regulation. Results revealed that the calcium current in the nerve terminal has typical G-protein-mediated changes in amplitude and activation kinetics. These suggest that the association of the presynaptic calcium channel with elements of the transmitter release site is necessary for the sensitivity of the current to G-protein regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem
Article Abstract:
Research into the role of G-proteins in the regulation of Ca2+ channels is presented, focusing on the GTP-bound form of kir/Gem.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Calmodulin supports both inactivation and facilitation of L-type calcium channels. Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels
- Abstracts: GABA receptors, granule cells and genes. Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
- Abstracts: Achilles and the maggots. The centenarian Golgi apparatus. Sulphur and holy water
- Abstracts: Laboratory simulations of sustained volcanic eruptions. Triggering basaltic volcanic eruptions by bubble-melt separation
- Abstracts: Absence of spectrally specific lateral inputs to midget ganglion cells in primate retina. Retinal ganglion cells act largely as independent encoders