Regulation of an extrathymic T-cell development pathway by oncostatin M
Article Abstract:
The expression of an oncostatin M transgene in the early T cell lineage stimulates the accumulation of mature and immature T cells in lymph nodes. This thymus-independent pathway of T-cell development helps in T-cell immunodeficiency. The administration of oncostatin M protein stimulates a 500-fold increase in Thy-1+ lymph node cells, and restores immune responsiveness in transgenic and non-transgenic mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Article Abstract:
A new study identifies two receptors for the tumour necrosis factor zTnF4 and establishes a link between zTNF4 and autoimmune disease. TaCI-Ig is identified as a possible treatment for human autoimmune disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Interleukin 21 and its receptor are involved in NK cell expansionand regulation of lymphocyte function
Article Abstract:
A class 1 cytokene receptor is identified and described in detail, with its probable role explained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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- Abstracts: Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Specificities of heparan sulphate proteoglycans in developmental processes
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