Regulation of the bacterial cell cycle by an integrated genetic circuit
Article Abstract:
A combination of biochemical, genetic and cell biological assays are used to map the connectivity of a regulatory network comprising two-component signalling proteins that can account for cell cycle oscillations in Caulobacter crescentus. The results have shown that master cell cycle regulator, CtrA, has triggered its own destruction by promoting cell division and inducing synthesis of essential regulator DivK, which has fed back to downregulate CckA immediately before S phase, accounting for cell cycle oscillations of CtrA in Caulobacter.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex
Article Abstract:
A novel NADH dehydrogenase module of respiratory complex I that is coupled to the central hydrogenosomal fermentative pathway is described. Phylogenetic analyses of hydrogenosomal complex I-like proteins Ndh51 and Ndh24 indicate that neither has a common origin with mitochondrial homologues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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The mechanism of cell differentiation in Bacillus subtilis
Article Abstract:
A model for the development of two different cell types from a single cell served by sporulation in Bacillus subtilis is presented. It is shown that this effect depends on the allosteric behavior of a key protein kinase and on a low rate of dephosphorylation by the corresponding phosphatase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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