Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
Article Abstract:
The class IV POU domain transcription factor, Brn-3.0, and the related factors Brn-3.1 and Brn-3.2 are involved in the survival and development of specific mammalian motor and sensory neurons. Brn-3.0 is crucial in the development of inferior olive, red nucleus, sensory ganglia and nucleus ambiguus. Homologous null mice Brn-3.0(super -/-) show physiological and behavioral defects. These show that the death of sensory and motor neurons is due to some aspects of neurotrophin-mediated signalling, and Brn-3.0 is involved in programmed gene expression, cell migration and neuron survival.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Molecular basis of the little mouse phenotype and implications for cell type-specific growth
Article Abstract:
A mutation in growth hormone releasing factor (GRF) receptor of the dwarf mouse 'little' alters Asp 60 to Gly, reducing cyclicAMP levels; this is the molecular basis for the phenotype. The regulatory strategy this reveals for growing diverse cell types in a single organ seems to be common to many mammalian organs. The shift in growth factor usage permits signal transduction pathways to regulate different sets of genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Eya protein phosphatase activity regulates six1-Dach-Eya transcriptional effects in mammalian organogenesis
Article Abstract:
Genetic interactions between sine oculis (Six) and eyes absent (Eya) factors that regulate precursor cell proliferation and survival during mammalian organogenesis are discussed. It is reported that Six1 is required for the development of murine kidney, muscle and inner ear, and that exhibits srynergistic genetic interactions with Eya factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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