Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
Article Abstract:
It has been established that ErbB2 is a mediator of IL-6 responses in a prostate carcinoma cell line, LNCaP. Functional ErbB2 is needed for both MAP kinase activation and IL-6 induced cell growth. The pleiotropic impact and potency of IL-6 on prostate cancer cell growth may be altered by the presence and level of the various ErbB kinases. This research has demonstrated how a cytokine receptor can diversify its signalling pathways by interacting with a growth-factor receptor kinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Sustained oscillations in living cells
Article Abstract:
It has been established that it is possible to control the precise dynamic state of a living system in a flow reactor. Research using a suspension of yeast cells showed that living cells can be maintained in a clear oscillating state indefinitely when starved cells, glucose and cyanide are pumped into a cuvette with outflow of surplus liquid. A number of steady states can be compared, with each steady state being analyzed for long periods of time.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Germ cells colonized by endosymbiotic bacteria
Article Abstract:
Wolbachia (Rickettsiaceae) is found in the reproductive tissues of arthropods. It is shown that Wolbachia become concentrated in the germ plasm of the Drosophila egg, and that the localization is dependent on the assembly of germ plasm. It is likely that the bacteria seen in ovarian nurse cells and oocytes respond to a component of pole plasm translated only after egg activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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